Research in the Cheer Lab is aimed at elucidating fundamental neural mechanisms
underlying motivated behaviors, and how these are modulated by the recently
described endogenous cannabinoid system.
This signaling network has been
involved in natural physiological processes such as pain perception,
thermoregulation and motor coordination. The system is also implicated in
maladaptive motivated behaviors such as drug addiction and obesity.
Our research
seeks to extract neurobiological correlates of certain behaviors, within
specifically defined anatomical frameworks to understand how key neural
circuits in the brain function.
We use advanced state-of-the-art
electrophysiological and neurochemical techniques to examine the activity
patterns of individual neurons as well as neuronal populations and how these are
regulated via neurotransmitters (dopamine in particular). We have
recently implemented the use of a sensor that allows for the simultaneous
measurement of neuronal firing and neurotransmitter release.
These techniques
are particularly useful for elucidating specific temporal relationships between
behavior and brain activity.
1. Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus.
Mason R, Cheer JF. Front Integr Neurosci. 2009 3:13 Epub Jun 15.
link to PDF
Postdoctoral position available
