Subsecond dopamine release in the nucleus accumbens predicts conditioned punishment and its successful avoidance.

Oleson EB, Gentry RN, Chioma VC, Cheer JF.
J Neurosci. 2012 Oct 17;32(42):14804-8.

On the role of subsecond dopamine release in conditioned avoidance.

Oleson EB, Cheer JF.
Front Neurosci. 2013 Jun 7;7:96..

Research in the Cheer Lab is aimed at elucidating fundamental neural mechanisms underlying motivated behaviors, and how these are modulated by the recently described endogenous cannabinoid system.
This signaling network has been involved in natural physiological processes such as pain perception, thermoregulation and motor coordination. The system is also implicated in maladaptive motivated behaviors such as drug addiction and obesity.

Our research seeks to extract neurobiological correlates of certain behaviors, within specifically defined anatomical frameworks to understand how key neural circuits in the brain function.

We use advanced state-of-the-art electrophysiological and neurochemical techniques to examine the activity patterns of individual neurons as well as neuronal populations and how these are regulated via neurotransmitters (dopamine in particular). We have recently implemented the use of a sensor that allows for the simultaneous measurement of neuronal firing and neurotransmitter release.

These techniques are particularly useful for elucidating specific temporal relationships between behavior and brain activity.

Contact :
J. F. Cheer Ph.D.

University of Maryland School of Medicine
Department of Anatomy and Neurobiology
20 Penn Street
Baltimore, MD 21201 - (410) 706-0112
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