Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release.

Oleson EB, Cachope R, Fitoussi A, Tsutsui K, Wu S, Gallegos JA, Cheer JF.
Neuropsychopharmacology. 2014 May;39(6):1441-52. doi: 10.1038/npp.2013.340. Epub 2013 Dec 18.

Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.

Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF.
Biol Psychiatry. 2014 Mar 15;75(6):487-98. doi: 10.1016/j.biopsych.2013.09.005. Epub 2013 Oct 17.

Research in the Cheer Lab is aimed at elucidating fundamental neural mechanisms underlying motivated behaviors, and how these are modulated by the recently described endogenous cannabinoid system.
This signaling network has been involved in natural physiological processes such as pain perception, thermoregulation and motor coordination. The system is also implicated in maladaptive motivated behaviors such as drug addiction and obesity.

Our research seeks to extract neurobiological correlates of certain behaviors, within specifically defined anatomical frameworks to understand how key neural circuits in the brain function.

We use advanced state-of-the-art electrophysiological and neurochemical techniques to examine the activity patterns of individual neurons as well as neuronal populations and how these are regulated via neurotransmitters (dopamine in particular). We have recently implemented the use of a sensor that allows for the simultaneous measurement of neuronal firing and neurotransmitter release.

These techniques are particularly useful for elucidating specific temporal relationships between behavior and brain activity.

Contact :
J. F. Cheer Ph.D.

University of Maryland School of Medicine
Department of Anatomy and Neurobiology
20 Penn Street
Baltimore, MD 21201 - (410) 706-0112
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